目的探讨1,2-二甲基-3-羟基-4-吡啶酮(deferipone,DFP)和牛磺酸联合作用对染铝大鼠大脑皮层抗氧化系统的影响。方法将70只健康SPF级雄性Wistar大鼠按体重随机分为7组,以灌胃方式染毒,其中,阴性对照组给予1 ml生理盐水,连续8周;铝染毒组、牛磺酸干预组、低剂量DFP干预组、高剂量DFP干预组、牛磺酸+低剂量DFP干预组和牛磺酸+高剂量DFP干预组在前4周分别给予281.40 mg/kg三氯化铝溶液,后4周分别给予1 ml生理盐水、400 mg/kg牛磺酸、13.82 mg/kg DFP、27.44 mg/kg DFP、400 mg/kg牛磺酸、400 mg/kg牛磺酸;牛磺酸+低剂量DFP干预组和牛磺酸+高剂量DFP干预组给予400 mg/kg牛磺酸6 h后分别给予13.82、27.44 mg/kg DFP,每天1次。测定大鼠大脑皮层SOD、GSH-Px活力和MDA含量。结果与阴性对照组比较,铝染毒组大鼠大脑皮层SOD和GSH-Px活力均较低,而MDA含量较高,差异有统计学意义(P<0.05)。与铝染毒组相比,在单独干预组中,仅高剂量DFP干预组可以显著提高SOD和GSH-Px活力,降低MDA的含量;牛磺酸干预组可以显著提高GSH-Px的活力水平以及降低MDA含量。在DFP和牛磺酸的联合作用下,大鼠大脑皮层的SOD和GSH-Px活力水平以及MDA含量均基本恢复正常。其中,与牛磺酸干预组和低剂量DFP干预组比较,牛磺酸+DFP干预组可以显著提高SOD和GSH-Px活力,降低MDA含量;且以牛磺酸+低剂量DFP干预组尤为显著。结论在本实验剂量范围内,牛磺酸和DFP联合干预可以对染铝大鼠大脑皮层的抗氧化系统起到保护作用,且效果优于牛磺酸或DFP单独干预。 Objective To investigate the effects of deferipone (DFP) combined with taurine on the antioxidant system in the cortex of rats with aluminum exposure. Methods Seventy healthy SPF male Wistar rats were randomly divided into 7 groups according to body weight. The rats in the negative control group were given 1 ml normal saline for 8 weeks. The aluminum exposure group, taurine intervention group Group, low-dose DFP intervention group, high-dose DFP intervention group, taurine + low-dose DFP intervention group and taurine + high-dose DFP intervention group were given 281.40 mg / kg of aluminum chloride solution in the first 4 weeks, Weeks were given 1 ml of saline, 400 mg / kg taurine, 13.82 mg / kg DFP, 27.44 mg / kg DFP, 400 mg / kg taurine, 400 mg / kg taurine; taurine + low dose DFP intervention group and taurine + high-dose DFP intervention group were given 400 mg / kg taurine for 6 h and then were given 13.82,27.44 mg / kg DFP once a day. The activities of SOD, GSH-Px and MDA in cerebral cortex of rats were measured. Results Compared with the negative control group, the activities of SOD and GSH-Px in the cerebral cortex of rats in the aluminum-exposed group were lower than those in the negative control group, while the content of MDA was higher in the rats in the aluminum-exposed group (P <0.05). Compared with the aluminum-exposed group, in the intervention group alone, high-dose DFP intervention group could significantly increase the activity of SOD and GSH-Px and decrease the content of MDA; taurine intervention group could significantly increase the activity of GSH-Px and Reduce MDA content. Under the combined action of DFP and taurine, the activity of SOD and GSH-Px and the content of MDA in cerebral cortex of rats returned to normal. Among them, compared with taurine intervention group and low-dose DFP intervention group, taurine + DFP intervention group could significantly increase the activity of SOD and GSH-Px and decrease the content of MDA; especially with taurine plus low-dose DFP intervention group . Conclusion The combination of taurine and DFP can protect the antioxidant system of the cerebral cortex of aluminum-exposed rats in this dose range, and the effect is better than taurine or DFP alone.