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应用光致发光荧光光谱技术，对７６例原发性肝癌、１６８例慢性肝病及３３例健康人进行全血卟啉类物质测定。结果表明，肝癌组锌卟啉和原卟啉峰值均明显高于慢性肝病组及对照组，尤其是原卟啉峰值可高于慢性肝病组１倍以上，各组间具有极显著性差异（Ｐ＜０．０１），若将原卟啉峰临界值定为４．５，其敏感度为８１．５８％，特异度为６１．３１％，与ＡＦＰ、ＧＧＴ－的诊断价值相似，可作为诊断原发性肝癌的临床敏感指标之一。特别是在ＡＦＰ阴性的肝癌中，原卟啉的增高率可达８２．３５％，若二者联合应用能提高敏感度至９６％。
Using photoluminescence fluorescence spectroscopy, whole blood porphyrins were measured in 76 cases of primary liver cancer, 168 cases of chronic liver disease and 33 healthy people. The results showed that the peak values of zinc porphyrin and protoporphyrin in liver cancer group were significantly higher than those in chronic liver disease group and control group, especially the peak value of protoporphyrin was higher than that in chronic liver disease group more than 1 times, and there was a significant difference between each group (P). <0.01), if the threshold value of the original porphyrin peak is set to 4.5, the sensitivity is 81.58% and the specificity is 61.31%. It is similar to the diagnostic value of AFP and GGT- and can be used as a diagnosis. One of the clinically sensitive indicators of primary liver cancer. Especially in AFP-negative liver cancer, the increase rate of protoporphyrin up to 82.35%, if the combination of the two can increase the sensitivity to 96%.