目的观察中晚期鼻咽癌三维调强放射治疗的近期临床疗效和毒性反应。方法将60例中晚期鼻咽癌患者随机分为两组:常规放疗组30例和三维调强放疗组30例,对其进行分组治疗后进行临床疗效观察与放疗后毒性反应分析。结果常规放疗组肿瘤消失4例占13.3%、肿瘤缩小13例占43.3%、肿瘤无变化13例占43.3%;三维调强放疗组肿瘤消失9例占30.0%、肿瘤缩小14例占46.7%、肿瘤无变化9例占30.0%,三维调强放疗组明显好于常规放疗组。三维调强放疗组出现放疗毒性反应者明显少于常规放疗组。结论三维调强放疗由于剂量分布上的优势,为局部中晚期鼻咽癌患者后程将剂量推量至更高水平放疗提供依据,同时还可以减少放疗毒性反应的发生。 Objective To observe the recent clinical efficacy and toxicity of three-dimensional IMRT for advanced nasopharyngeal carcinoma. Methods Sixty patients with advanced nasopharyngeal carcinoma were randomly divided into two groups: conventional radiotherapy group (30 cases) and three-dimensional intensity-modulated radiotherapy group (30 cases). The clinical efficacy and toxicity after radiotherapy were analyzed. Results In the conventional radiotherapy group, the tumor disappeared in 4 cases (13.3%), the tumors reduced in 13 cases (43.3%), the tumors did not change in 13 cases (43.3%), the tumors disappeared in 9 cases (30.0%), the tumors reduced in 14 cases (46.7% There was no change in tumor in 9 cases (30.0%). Three-dimensional intensity-modulated radiotherapy was significantly better than conventional radiotherapy. Three-dimensional IMRT group radiotherapy toxicity was significantly less than the conventional radiotherapy group. Conclusion Three-dimensional intensity modulated radiotherapy because of the advantages of dose distribution for the late course of nasopharyngeal carcinoma in patients with doses to a higher level to provide the basis for radiotherapy, but can also reduce the incidence of radiotherapy toxicity.