论文部分内容阅读
随着遗传毒理学的发展,从环境化合物中已发现大量的诱变物质。人们对这些诱变物质在环境中造成的远期影响越来越表示关切。为此,建立起种种快速灵敏的方法,以对众多化合物的遗传毒性作出评价和预报。然而遗憾的是,已经发现的诱变物并不能简单地予以去除,原因是有些诱变剂目前仍有重要的使用价值,如抗癌药物和抗寄生虫药物等。由此抗诱变研究应运而生,成为最引人注目的课题之一。根据Clarke(1975)年的定义,抗诱变作用(Antimutagenesis)就是外部因子特异
With the development of genotoxicity, a large number of mutagens have been found from environmental compounds. There is growing concern about the long-term impact of these mutagens in the environment. To this end, a variety of rapid and sensitive methods have been established to evaluate and predict the genotoxicity of many compounds. Unfortunately, the mutagens that have been found can not be simply removed because some mutagens currently have important use-value, such as anti-cancer drugs and anti-parasitic drugs. Therefore, anti-mutagenesis research came into being, becoming one of the most striking issues. According to the definition of Clarke (1975), the anti-mutagenesis is an extrinsic factor-specific