迷走传入神经元接受脑-肠肽的信号刺激并传递至下丘脑,对摄食行为进行调节。胆囊收缩素(CCK)作为一种重要的胃肠激素,在脑-肠轴调控机制中起关键作用,它能够兴奋迷走传入神经元,调节某些G蛋白偶联受体的兴奋性以及其他肽类神经递质的释放。本文就胃肠激素参与脑-肠轴调控机制的进展,特别是CCK在迷走传入神经途径中的“枢纽”作用作一综述。 Vagal afferent neurons receive signal stimulation of brain-gut peptides and transmit to the hypothalamus to regulate feeding behavior. As an important gastrointestinal hormone, cholecystokinin (CCK) plays a pivotal role in the regulation of brain-gut axis. It can excite vagal afferent neurons, regulate the excitability of certain G-protein coupled receptors and other Release of peptide neurotransmitters. This article reviews the progress of gastrointestinal hormones involved in the regulation of brain-gut axis, especially the “hub” effect of CCK in vagal afferent pathway.