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目的 :分析影响肾移植术后重症肺部感染患者预后的相关因素 ,找出影响生存时间的主要因素 ,为临床治疗提供参考。方法 :回顾 46例肾移植术后重症肺部感染患者的临床资料 ,分析 PRA、感染发生时间、免疫抑制方案、抗感染治疗方案等 9项相关因素 ,应用 Cox比例风险模型检验各因素与肺部感染患者生存时间的关系。结果 :术后发生感染时间、预防性应用更昔洛韦、应用 OKT3及抗感染治疗方案是影响肾移植术后肺部感染患者预后的 4个主要因素 ,各种口服免疫抑制剂方案对预后的影响无显著性差异。结论 :预防性应用更昔洛韦和≥ 3种联合抗感染治疗是影响肾移植术后重症肺部感染患者预后的保护因素 ,感染发生时间和应用 OKT3是危险因素
OBJECTIVE: To analyze the related factors that influence the prognosis of patients with severe pulmonary infection after renal transplantation and find out the main factors that affect the survival time, so as to provide reference for clinical treatment. Methods: The clinical data of 46 patients with severe pulmonary infection after renal transplantation were retrospectively analyzed. Nine related factors such as PRA, time of onset of infection, immunosuppressive regimen and anti-infective treatment were analyzed. Cox proportional hazards model was used to test the correlation between the factors Relationship between survival time of infected patients. Results: Postoperative infection time, prophylactic use of ganciclovir, application of OKT3 and anti-infective treatment regimen were the four major factors affecting the prognosis of patients with pulmonary infection after renal transplantation. The efficacy of various oral immunosuppressive regimens for prognosis No significant difference in impact. CONCLUSIONS: Prophylactic application of ganciclovir and ≥ 3 combinations of anti-infectives are protective factors that influence the prognosis of patients with severe pulmonary infection after kidney transplantation. The timing of infection and the use of OKT3 are risk factors