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目的探讨头孢类抗生素联合阿奇霉素治疗小儿急性下呼吸道感染的效果及安全性。方法 92例急性下呼吸道感染患儿,随机分为对照组与观察组,各46例。对照组患儿采用头孢替安治疗,观察组患儿采用头孢替安联合阿奇霉素治疗,对比两组患儿的治疗效果及不良反应发生率。结果观察组治疗总有效率为95.65%,明显高于对照组的80.43%(P<0.05)。观察组的发热、咳嗽、喘息及肺部啰音的消失时间明显短于对照组(P<0.05)。对照组不良反应发生率为4.35%,观察组为8.70%,两组比较差异无统计学意义(P>0.05)。结论头孢类抗生素联合阿奇霉素治疗小儿急性下呼吸道感染具有疗效确切、安全性高等优点,值得临床推广应用。
Objective To investigate the efficacy and safety of cephalosporins combined with azithromycin in the treatment of children with acute lower respiratory tract infection. Methods A total of 92 children with acute lower respiratory tract infection were randomly divided into control group and observation group, with 46 cases in each. The control group of children treated with cefotiam, the observation group of children treated with cefotiam azithromycin combined treatment, the treatment of children in both groups and the incidence of adverse reactions. Results The total effective rate of the observation group was 95.65%, which was significantly higher than that of the control group (80.43%, P <0.05). The observation group’s fever, cough, wheezing and pulmonary rales disappeared significantly shorter than the control group (P <0.05). The incidence of adverse reactions in the control group was 4.35%, and the observation group was 8.70%. There was no significant difference between the two groups (P> 0.05). Conclusion The combination of cephalosporin antibiotics and azithromycin in children with acute lower respiratory tract infection has the advantages of definite curative effect and high safety. It is worthy of clinical application.