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根据用裸鼠植入人结肠癌试验所获得的结果表明,注入放射线标记的高亲合力抗癌胚抗原(CEA)单克隆抗体(McAb)的F(ab′)_2和Fab片段,肿瘤组织与正常组织所摄入的放射活性浓度的比率,显著地高于完整的McAb。用这两种片段测试了确诊为结直肠癌的两组患者。第一组有31例诊断为结直肠癌的病人,其中10例为原发癌、13例为局部肿瘤复发、21例为转移瘤。给他们注射~(123)I标记的抗CEAMcAb的F(ab′)_2片段(14例)和Fab片段(17例),在注射后的第6、24小时用旋转式
According to the results obtained from the nude mice implanted with human colon cancer test, the radiolabeled high affinity anti-carcinoembryonic antigen (CEA) monoclonal antibody (McAb) F(ab’)_2 and Fab fragments were injected, and the tumor tissues were The ratio of radioactive concentrations ingested by normal tissues is significantly higher than that of intact McAb. Two groups of patients diagnosed with colorectal cancer were tested with these two fragments. The first group included 31 patients diagnosed with colorectal cancer, including 10 primary cancers, 13 local tumor recurrences, and 21 metastatic tumors. They were injected with ~(123)I-labeled anti-CEAMcAb F(ab’)_2 fragments (14 cases) and Fab fragments (17 cases), and they were rotated at 6 and 24 hours after injection.