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目的:观察动物灌胃(ig)玄归止痛滴丸的急性毒性和长期毒性,确定无毒反应的剂量,评估玄归止痛滴丸长期用药安全性。方法:以最大浓度最大体积的玄归止痛滴丸ig ICR种健康小白鼠,测定最大耐受量;以高、中、低3个剂量对大鼠进行连续ig给药,连续6周,给药6周后每组取2/3只动物进行检测,观察大鼠的一般体征、体重、食物消耗量以及血液细胞学、生化学指标、组织病理学检查,余下动物停药后继续饲养2周后进行相应检查。结果:小鼠1 d内ig玄归止痛滴丸最大耐受量20 g·kg~(-1),相当于临床日剂量的869倍,各给药组与对照组检查指标,差异均无统计学意义(P>0.05)。结论:ig玄归止痛滴丸对小鼠、大鼠均无明显的毒性反应。
Objective: To observe the acute toxicity and long-term toxicity of Xuanguizhi Tong Dripping Pill given by animal, to determine the dose of non-toxic reaction and to evaluate the long-term safety of Xuanguizhi Tong Dripping Pill. Methods: The maximal volume of XuanGuiJiJiu pill ig ICR healthy mice, measured the maximum tolerated dose; high, medium and low doses of three doses of continuous ig administration to rats for 6 weeks, administration After 6 weeks, 2/3 animals in each group were tested for signs, body weight, food consumption and blood cytology, biochemical indicators, histopathological examination, the remaining animals after feeding for 2 weeks Check accordingly. Results: The maximum tolerated dose of ig Xuangui Dacheng Dripping Pills was 20 g · kg ~ (-1) in mice within 1 d, which was equivalent to 869 times of the clinical daily dose. There was no statistical difference between the two groups Significance (P> 0.05). Conclusion: ig Xuan Gui Zhitong pill has no obvious toxic reaction in mice and rats.