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目的 :探讨喉癌患者血浆前列腺素 E2 (PGE2 )水平的临床意义。方法 :应用放射免疫分析法测定 35例喉癌患者血浆 PGE2 水平。结果 :喉癌患者血浆 PGE2 水平显著高于正常对照组 (P <0 .0 5 ) ,但与喉癌的临床分期无关 (P >0 .0 5 )。喉癌患者血浆 PGE2 水平术后较术前显著下降 (P <0 .0 5 ) ,但术后复发者比未复发者的血浆PGE2 水平明显增高 (P<0 .0 1)。结论 :测定患者血浆中 PGE2 含量 ,对喉癌的诊断及预后判断有参考价值
Objective: To investigate the clinical significance of plasma prostaglandin E2 (PGE2) levels in patients with laryngeal cancer. Methods: Plasma PGE2 levels were measured in 35 patients with laryngeal cancer by radioimmunoassay. Results: Plasma PGE2 level in patients with laryngeal cancer was significantly higher than that in the normal control group (P <0.05), but not in clinical stage (P> 0.05). Plasma PGE2 levels in patients with laryngeal cancer were significantly lower than those before surgery (P <0.05), but plasma PGE2 levels were significantly higher in patients with laryngeal cancer than those without recurrence (P <0.01). Conclusion: The determination of plasma PGE2 content in patients with laryngeal cancer diagnosis and prognosis of a reference value