目的探讨１５３Ｓｍ乙二胺四甲撑膦酸（ＥＤＴＭＰ）内照射治疗剂量。方法以Ｃ语言编制ＳｍＤＯＳＥ程序，剂量分析根据ＩＣＲＰ１９８７年和ＴｕｒｎｅｒＪＨ１９８９年的药物动力学资料，对１１６例用１５３ＳｍＥＤＴＭＰ（１５３２１７±２７６０２ＭＢｑ，２６２７ＭＢｑ／ｋｇ）治疗的癌性骨痛患者进行骨辐射剂量和剂量效应关系分析。结果尿排出活度、骨吸收活度和骨累积活度分别为４８１０±２３９０２ＭＢｑ、１０５１１７±２８０１ＭＢｑ和６７４６８０２±１９４９２９０ＭＢｑ·ｈ。红骨髓吸收剂量为２１６９７±６２７９ｃＧｙ，低于２８５ｃＧｙ安全剂量范围。结论１５３ＳｍＥＤＴＭＰ内照射治疗剂量的分析有助于临床治疗剂量和剂量效应关系的研究 Objective To investigate the therapeutic dose of 153Sm ethylenediamine tetramethylene phosphonic acid (EDTMP). Methods The SmDOSE program was compiled in C language. According to the ICRP (1987) and TurnerJH (1989), the data of 116 patients with cancerous bone pain treated with 153SmEDTMP (153217 ± 27602MBq, 2627MBq / kg) The patients were analyzed the relation between dose and dose of bone radiation. Results Urinary excretion activity, bone resorption activity and bone cumulative activity were 481 ± 23902 MBq, 105117 ± 2801 MBq and 6746802 ± 1949290 MBq · h, respectively. Red bone marrow absorption dose of 216  97 ± 62  79cGy, lower than 285cGy safe dose range. Conclusion The analysis of 153SmEDTMP internal radiation treatment dose is helpful to study the relationship between dose and dose  effect