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目的研究泮托拉唑冻干粉剂对消化性溃疡合并上消化道出血的疗效。方法回顾分析2006—2007年56例经内镜证实的消化性溃疡合并上消化道出血患者,随机分为两组,其中泮托拉唑治疗组32例,奥美拉唑治疗组24例,分别以泮托拉唑及奥美拉唑40mg静滴每日2次。结果泮托拉唑组29例(90.63%)患者3d内止血,疗效判断为显效;3例(9.37%)患者4～5d内止血,疗效判断为有效;无效0例,总有效率为100%。奥美拉唑组22例(91.67%)患者3d内止血,疗效判断为显效;2例(8.33%)患者4～5d内止血,疗效判断为有效;无效0例,总有效率为100%。两组在治疗上消化道出血显效率及有效率方面无统计学意义(P>0.05)。结论泮托拉唑是治疗消化道出血的有效药物。
Objective To study the effect of pantoprazole lyophilized powder on peptic ulcer with upper gastrointestinal hemorrhage. Methods Retrospective analysis of 56 cases of endoscopic peptic ulcer patients with upper gastrointestinal bleeding from 2006 to 2007 were randomly divided into two groups, including 32 cases in the group of pantoprazole and 24 cases in the group of omeprazole, respectively To pantoprazole and omeprazole 40mg intravenously 2 times a day. Results Thirty patients (30.63%) in the pantoprazole group had hemostasis within 3 days, and the curative effect was judged to be effective. In 3 patients (9.37%), the bleeding was stopped within 4 to 5 days, and the curative effect was judged as effective. . Twenty-two patients (91.67%) in Omeprazole group had hemostasis within 3 days, and the curative effect was judged to be effective. Two patients (8.33%) stopped bleeding within 4-5 days, and the curative effect was judged to be effective; 0 was ineffective and the total effective rate was 100%. There was no significant difference between the two groups in the treatment of upper gastrointestinal bleeding efficiency and efficiency (P> 0.05). Conclusion Pantoprazole is an effective drug for the treatment of gastrointestinal bleeding.