目的　了解我院抗菌药物的使用现状和存在问题,为抗菌药物的合理应用和宏观管理提供科学的依据。方法　采用分层系统抽样,对我院1995 年11 月～1996 年10 月期间的住院患者抗菌药物的应用现状及其合理性进行回顾性调查,全部调查资料录入计算机进行统计分析。结果　共调查1932 份病历,抗菌药物总的使用率为76.7% ,以单种应用为主,占61.2% ,主要为静脉给药,其中头孢菌素类占第一位,其次为青霉素类和喹诺酮类,三者共占64.5% ;多数使用国产基础抗菌药物,但进口抗菌药物所占金额比重较大;抗菌药物费占整个药费的26.3% ;且大部分医师能做到合理应用。结论　加强抗菌药物合理应用的管理非常重要 Objective To understand the status quo and existing problems of antimicrobial use in our hospital and provide a scientific basis for the rational application and macro management of antimicrobial agents. Methods The stratified systematic sampling was used to retrospectively investigate the status quo and rationality of antibacterials in hospitalized patients from November 1995 to October 1996 in our hospital. All the survey data were entered into the computer for statistical analysis. Results A total of 1932 medical records were investigated. The overall use rate of antimicrobial agents was 76.7%, mainly in single application, accounting for 61.2%, mainly for intravenous administration, of which cephalosporins accounted for the first place, followed by penicillins and quinolones Class, the three accounted for a total of 64.5%; the majority of domestic use of basic antibacterial drugs, but the proportion of imported antimicrobial drugs accounted for a larger proportion; antibacterial drugs account for 26.3% of the entire drug costs; and most physicians can do a reasonable application. Conclusion It is important to strengthen the management of rational use of antimicrobial agents