以免疫缺陷过筛试验无异常发现的30例反复呼吸道感染患儿为研究对象,分反覆肺炎组(14例)和反复气道炎组(16例)。采用相应的单克隆抗体用改良的单向免疫扩散法检测血清IgG亚类水平,发现其中5例IgG亚类含量低于同龄正常值G_1SD(均为反复肺炎组),占该组总例数的35.7%。本文结合5例的临床与实验资料,对IgG亚类缺陷病的诊断与治疗进行探讨。 A total of 30 children with recurrent respiratory tract infection without abnormal findings in immunodeficiency screening test were divided into pneumonia group (n = 14) and recurrent airway inflammation group (n = 16). Using the corresponding monoclonal antibody with improved one-way immunodiffusion method to detect serum IgG subclass levels, found that 5 cases of IgG subclass content was lower than normal age group  G_1SD (both repeated pneumonia group), accounting for the total number of cases Of the 35.7%. In this paper, five cases of clinical and experimental data, the diagnosis and treatment of IgG subclass deficiency disease are discussed.