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为了研究消化系统恶性肿瘤的增殖活性及其与肿瘤组织学分级和淋巴结转移之间的关系,我们应用常规石蜡切片,以PCNA的单克隆抗体检测PCNA在19例胃腺癌,5例肠腺癌及6例食道鳞癌中的表达,并分别对PCNA增殖指数进行t检验。结果表明:PCNA增殖指数在消化道恶性肿瘤组织中明显升高,与正常组织间差异有显著性(P0.05)。此外还发现,癌旁不典型增生组织中的PCNA增殖指数,不仅高于正常组织,而且超过了癌组织。
To investigate the relationship between the proliferation activity of malignant tumors in the digestive system and its relationship with tumor histological grade and lymph node metastasis, we used routine paraffin sections to detect PCNA with PCNA monoclonal antibodies in 19 cases of gastric adenocarcinoma and 5 cases of intestinal adenocarcinoma and Six cases of esophageal squamous cell carcinoma were expressed and t-tests were performed on PCNA proliferation index. The results showed that the proliferation index of PCNA was significantly higher in malignant tumors of the digestive tract, and there was a significant difference from normal tissues (P < 0.05), but there was no difference between tumor groups with different histological grades and lymph node metastases. Significant (P>0.05). In addition, it was found that the proliferation index of PCNA in cancerous atypical hyperplasia tissues was not only higher than normal tissues but also exceeded cancerous tissues.