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转移性结直肠癌治疗已从单纯化学药物治疗向与分子靶向药物联合的方向转化,传统持续给药至疾病进展或患者不能耐受的维持治疗策略也受到许多新策略的挑战。维持治疗不仅可以巩固一线治疗的疗效,而且可以减轻化学治疗药物的累积性毒性,有效提高患者生活质量,延缓疾病进展,并最终延长总生存期。维持治疗已成为转移性结直肠癌化学治疗的研究热点。
The treatment of metastatic colorectal cancer has been transformed from simple chemotherapeutic treatment to combination with molecular targeted drugs. The traditional maintenance therapy strategies that are continuously administered until the disease progresses or patients can not tolerate are also challenged by many new strategies. Maintenance therapy can not only consolidate the efficacy of first-line treatment, but also reduce the cumulative toxicity of chemotherapeutic drugs, effectively improve the quality of life of patients, delay the progress of the disease, and ultimately extend the overall survival. Maintenance therapy has become the research focus of metastatic colorectal cancer chemotherapy.