作者们于1976～1982年对109例复发性喉乳头状瘤患者用CO_2激光治疗,并于创面涂以鬼臼树脂(podophyllum resin),共作了548次激光切除手术,其中32例(29.4%)的喉乳头状瘤病变同时累及上呼吸道和消化道,病变同时侵及气管支气管分支处的20例(18.3%),腭部9例(8.3%),有4例怀疑侵及肺实质。本病可发生于任何年龄,但多见于儿童和青年,老年人少见。本组病例发病年龄在10岁以下者有48例,其中40例在5岁以内。在开始激光治疗前,这109例经过1,050次一般手术切除,而近10%未根除病变。一般认为喉乳头状瘤多由乳多泡病毒引起,近年来用免疫过氧化酶染色,证实成年人的喉乳头状瘤50%为人类乳头状瘤病毒所致。Lancaster等(1981)用掺假脱氧核苷酸杂交法显示在喉乳头 The authors used CO 2 laser in the treatment of 109 patients with recurrent laryngeal papilloma from 1976 to 1982. They were treated with podophyllum resin on the wound surface. A total of 548 laser ablation procedures were performed, including 32 cases (29.4%). The laryngeal papilloma lesions of the same time involving the upper respiratory tract and digestive tract at the same time invading the tracheobronchial branch in 20 cases (18.3%), 9 cases (8.3%) of the ankle, and 4 cases of suspected invasion of lung parenchyma. The disease can occur at any age, but it is more common in children and young people than in the elderly. There were 48 cases of the age of onset in this group of patients under the age of 10, of which 40 cases were within 5 years of age. Prior to the start of laser treatment, 109 of these 109 cases had undergone general surgical resection and nearly 10% had not eradicated the disease. Laryngeal papilloma is generally believed to be caused by papovaviruses. In recent years, immunoperoxidase staining has been used to verify that 50% of adult laryngeal papillomas are caused by human papillomavirus. Lancaster et al. (1981) showed adulterated nipples using adulterated deoxynucleotide hybridization