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目的探讨非典型抗精神病药利培酮对泌乳素的影响及其与临床疗效的关系。方法采用固定剂量利培酮（６ｍｇ／ｄ）治疗慢性、男性精神分裂症３０例，疗程１２周；在治疗前后评定ＰＡＮＳＳ量表，并用放射免疫法测查血浆中泌乳素（ＰＲＬ）浓度。以１６例健康人为对照。结果治疗后，患者ＰＡＮＳＳ总分及其分量表均显著降低；治疗前患者ＰＲＬ较对照组显著降低，治疗后显著性增高。治疗前后泌乳素差值与ＰＡＮＳＳ阳性症状分量表减分值、减分率显著相关。结论利培酮对精神分裂症血泌乳素水平有明显影响，而且泌乳素水平与临床疗效相关。
Objective To investigate the effect of atypical antipsychotic risperidone on prolactin and its relationship with clinical efficacy. Methods Routine doses of risperidone (6 mg / d) were given to 30 chronic and male schizophrenic patients for 12 weeks. The PANSS scale was assessed before and after treatment and plasma prolactin (PRL) concentration was measured by radioimmunoassay. Take 16 healthy people as control. Results After treatment, the total score of PANSS and its subscale were significantly decreased. The PRL of patients before treatment was significantly lower than that of the control group and significantly increased after treatment. Prolactin difference before and after treatment and PANSS positive symptom subscale scores, reduction rate was significantly correlated. Conclusions Risperidone has a significant effect on the level of prolactin in schizophrenia, and the level of prolactin is related to the clinical efficacy.