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目的分析糖皮质激素不同给药方式治疗季节性变应性鼻炎合并哮喘的疗效。方法选取季节性变应性鼻炎合并哮喘患者90例,随机分为A组、B组、C组各30例,3组均给予布地奈德治疗,用药方式:A组鼻喷治疗,B组口吸治疗,C组鼻喷+口吸治疗,比较3组患者血清总Ig E、白细胞介素-5(IL-5)、嗜酸性粒细胞阳离子蛋白(ECP)水平、鼻炎评分、哮喘评分及咳嗽消失时间。结果治疗后3组患者血清总Ig E、IL-5、ECP水平,以及鼻炎评分、哮喘评分均低于治疗前,差异有统计学意义(P<0.05);组间比较差异均无统计学意义(P>0.05)。C组患者咳嗽消失时间短于A、B组,差异有统计学意义(P<0.05)。结论鼻喷、口吸及鼻喷+口吸三种方法治疗季节性变应性鼻炎合并哮喘均能取得显著效果,但鼻喷+口吸糖皮质激素治疗可显著缩短咳嗽消失时间。
Objective To analyze the effects of different administrations of glucocorticoids on patients with seasonal allergic rhinitis and asthma. Methods Ninety patients with seasonal allergic rhinitis and asthma were randomly divided into A group, B group, and C group, 30 cases each. Budesonide was given to all three groups. The mode of administration was nasal spray in group A and group B C group, nasal spray and mouth-suction therapy. The levels of total serum IgE, IL-5, ECP, rhinitis score, asthma score and cough Disappear time Results The levels of total serum IgE, IL-5 and ECP, rhinitis score and asthma score of the three groups after treatment were lower than those before treatment (P <0.05). There was no significant difference between the two groups (P> 0.05). C group of patients with cough disappeared shorter than A, B group, the difference was statistically significant (P <0.05). Conclusions Nasal spray, oral inhalation and nasal spray + oral inhalation are effective in treating seasonal allergic rhinitis with asthma. However, nasal spray + oral inhaled glucocorticoid treatment can significantly shorten the time of cough disappearance.