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目的:观察疏风宣肺解毒方的止咳作用,并分析探讨其作用机理。方法:使用豚鼠枸橼酸致咳法,观察疏风宣肺解毒方的止咳作用,并检测豚鼠肺组织中的SOD、MDA和IL-2因子,观察其对气管平滑肌的影响。结果:疏风宣肺解毒方的大、中剂量组与空白对照组相比,豚鼠的咳嗽潜伏期显著延长,咳嗽次数明显减少(P<0.05),疏风宣肺解毒方并能提高肺组织SOD、IL-2含量,降低MDA含量,其解痉率与空白对照组相比差异均有统计学意义(P<0.01)。结论:疏风宣肺解毒方具有较好的止咳作用,其机理可能通过影响SOD、MDA应激反应指标和IL-2炎症因子,并解除气管平滑肌痉挛而发挥止咳作用。
Objective: To observe the cough effect of Shufeng Xuanfei Jiedu Fang and analyze its mechanism. Methods: The cough method induced by citric acid in guinea pigs was used to observe the cough-relieving effect of Shufeng Xuanfei Jiedu Decoction. The levels of SOD, MDA and IL-2 in lung tissue of guinea pigs were measured to observe their effects on tracheal smooth muscle. Results: Compared with the blank control group, the cough latency of guinea pigs was significantly prolonged and the number of coughs was significantly decreased (P <0.05). Shufeng Xuanfei Jiedu Decoction and the lung tissue SOD , IL-2 content, decreased MDA content, the rate of antispasmodic compared with the blank control group were statistically significant (P <0.01). Conclusion: Shufeng Xuanfei Jiedu Decoction has good antitussive action. Its mechanism may exert antitussive effect by affecting the indexes of SOD and MDA stress response and IL-2 inflammation and relieving the spasm of tracheal smooth muscle.