由于卡瓦胡椒Piper methysticaum存在肝毒性,该植物制品最近已从德国市场撤消,但其肝毒性的原因尚不清楚。鉴于细胞色素P450酶在肝代谢和清除外来抗生素中起重要作用,作者研究了该植物提取物对细胞色素P450 3A4(CYP3A4)的影响。 Because of the hepatotoxicity of Piper methysticaum, the plant has recently been withdrawn from the German market, but the reason for its hepatotoxicity is unclear. In view of the important role of cytochrome P450 enzymes in hepatic metabolism and clearance of foreign antibiotics, the authors studied the effect of this plant extract on cytochrome P450 3A4 (CYP3A4).