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目的：分析鼻咽癌细胞的遗传变异特性。方法：①应用比较基因组杂交（CGH）技术检测47例NPC活检组织DNA拷贝数的改变；②应用微卫星序列分析16号染色体缺失情况。结果：发现与NPC相关的7个DNA拷贝高频增加区和7个高频缺失区：增加的染色体为1q、3q、4、6q、8q、12和18；缺失的染色体有1p、3p、gq、11q、14、16和19P。16号染色体进行了微卫星序列分析，检测出两个异常明显的区域：16p12．3和16q24．3。结论：鼻咽癌具有染色体变异，其中增加最多的是染色体1q和12，缺失最多的是染色体1p和16。
Objective: To analyze the genetic variation of nasopharyngeal carcinoma cells. Methods: ① The DNA copy number of 47 cases of NPC biopsy was detected by CGH; ② The microsatellite analysis was used to analyze the deletion of chromosome 16. RESULTS: Seven high frequency DNA deletion regions and seven high frequency deletion regions were found associated with NPC. The increased chromosomes were 1q, 3q, 4, 6q, 8q, 12 and 18, and the missing chromosomes were 1p, 3p, gq , 11q, 14, 16 and 19P. Microsatellite analysis of chromosome 16 revealed two abnormally distinct regions: 16p12.3 and 16q24.3. Conclusion: There are chromosomal variation in NPC, with chromosome 1q and 12 increasing most, and chromosomes 1p and 16 missing the most.