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目的：建立大鼠溃疡性结肠炎模型。方法：令大鼠每天自由饮用３％硫酸葡聚糖（ＤＳＳ）溶液，每天观察症状。１０天后行结肠镜检查，并解剖取出大肠作肉眼观察及切片组织学研究。结果：所观察的症状、内镜像、肉眼病理及组织学病理改变均与人类溃疡性结肠炎类似。结论：该模型重复性良好，可作为溃疡性结肠炎模型用于研究该病的病理机制及治疗新药的开发
Objective: To establish a rat ulcerative colitis model. Methods: Rats were allowed to drink 3% dextran sulfate (DSS) solution daily for observing the symptoms. Colonoscopy was performed 10 days later, and the colon was removed for dissection and histological examination. RESULTS: The observed symptoms, endoscopic findings, gross pathology, and histopathological changes were similar to those of human ulcerative colitis. Conclusion: This model has good repeatability and can be used as a model of ulcerative colitis to study the pathological mechanism of the disease and the development of new drugs