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目的观察和了解糖尿病与白血病之间的关系。方法收集、整理资料,报道2例糖尿病并发白血病的诊治经过,并对其进行探讨分析。结果两例患者分别于确诊为2型糖尿病后4、6年发生白血病,两例患者家族中均有2型糖尿病患者。其中1例因病情危重,合并感染死亡,另1例待行骨髓移植。结论2型糖尿病的遗传易感性较1型强,且更为复杂,分析研究两例2型糖尿病并发白血病患者资料,提出糖尿病与白血病之间可能存在直接或间接相关因素,其白血病的病变主要发生在早期造血干细胞水平。
Objective To observe and understand the relationship between diabetes and leukemia. Methods Collected and collated the data, reported the diagnosis and treatment of 2 cases of diabetes complicated with leukemia, and discussed and analyzed. Results Two patients developed leukemia at 4 and 6 years after diagnosis of type 2 diabetes, respectively. Both families had type 2 diabetes mellitus. One case of critical illness due to infection, the death of the infection, the other one to be treated with bone marrow transplantation. Conclusion The genetic susceptibility of type 2 diabetes is stronger than that of type 1 and more complicated. The data of two cases of type 2 diabetes mellitus complicated with leukemia are analyzed. It is suggested that there may be direct or indirect related factors between diabetes mellitus and leukemia. In the early stage of hematopoietic stem cells.