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目的观察手术去势联合间歇性雄激素全阻断疗法治疗局部进展期前列腺癌的临床疗效。方法 90例局部进展期前列腺癌患者,随机分为对照组和观察组,每组45例。其中对照组患者采用手术去势进行治疗,观察组患者采取手术去势联合间歇性雄激素全阻断疗法治疗。观察两组的临床疗效。结果观察组患者的前列腺特异性抗原(PSA)水平和生活质量指数(QOL)评分分别为(3.76±1.45)ng/L、(89.27±4.28)分,对照组分别为(14.35±2.37)ng/L、(74.64±4.83)分,观察组患者显著优于对照组,差异具有统计学意义(P<0.05)。结论手术去势联合间歇性雄激素全阻断疗法治疗局部进展期前列腺癌患者疗效显著,有利于提高患者生活质量,值得临床推广应用。
Objective To observe the clinical efficacy of surgical castration plus intermittent androgen blockade in the treatment of locally advanced prostate cancer. Methods Ninety patients with locally advanced prostate cancer were randomly divided into control group and observation group, 45 cases in each group. The control group of patients with surgical castration for treatment, the observation group of patients with surgical castration combined with intermittent androgen blockade therapy. The clinical efficacy of the two groups was observed. Results The levels of PSA and QOL in the observation group were (3.76 ± 1.45) ng / L and (89.27 ± 4.28), respectively, while those in the control group were (14.35 ± 2.37) ng / L, (74.64 ± 4.83) points, the observation group was significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion Surgical castration combined with intermittent androgen blockade therapy for the treatment of locally advanced prostate cancer patients with significant effect, is conducive to improving the quality of life of patients, it is worth promoting the clinical application.