目的:探讨抗精神病药物致恶性综合征(NMS)的临床特点与治疗。方法:回顾性分析16例因长期服用抗精神病药致NMS的临床资料。结果:发病后4 d内确诊9例,全部存活,几乎无明显后遗症;发病4～7 d确诊6例均存活;第8天后确诊1例,死亡。结论:长期服用抗精神病药易致NMS,以肌强直、发热、CK值增高为主要特征。其预后重点在早期诊断,早期治疗,尽可能避免或减少并发症的发生。 Objective: To investigate the clinical features and treatment of antipsychotic-induced malignant syndrome (NMS). Methods: A retrospective analysis of 16 cases of long-term use of antipsychotics induced NMS clinical data. Results: Nine cases were diagnosed within 4 days after onset, all survived with almost no sequelae. Six cases diagnosed 4 to 7 days after the onset of disease survived. One case was diagnosed after the 8th day and died. Conclusion: Long-term use of antipsychotics easily lead to NMS, with myotonia, fever, increased CK value as the main feature. The prognosis focuses on early diagnosis and early treatment, to avoid or reduce the incidence of complications as much as possible.