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目的 :探讨细胞因子在病毒性脑炎发病中的作用及意义。方法 :对 30例确诊为急性病毒性脑炎患儿 (其中 8例为重症脑炎 ,伴频繁抽搐、昏迷 )血清、脑脊液检测了 TNF- α(肿瘤坏死因子 )。结果 :急性病毒性脑炎血清、脑脊液 TNF- α较正常对照组明显升高 ,且重症组患儿明显高于轻症组。结论 :病毒性脑炎的发病与 TNF- α密切相关 ,且血清、脑脊液 TNF- α对预测小儿病毒性脑炎的病情变化及预后有一定的意义
Objective: To investigate the role and significance of cytokines in the pathogenesis of viral encephalitis. Methods: TNF-α (tumor necrosis factor) was detected in serum and cerebrospinal fluid of 30 children diagnosed as acute viral encephalitis (8 cases were severe encephalitis, with frequent convulsions and coma). Results: The levels of TNF-α in serum and cerebrospinal fluid of patients with acute viral encephalitis were significantly higher than those in normal control group, and those in severe group were significantly higher than those in mild group. Conclusions: The incidence of viral encephalitis is closely related to TNF-α, and serum and cerebrospinal fluid TNF-α have certain significance in predicting the change and prognosis of children with viral encephalitis