论文部分内容阅读
类胰高糖素肽-1(GLP-1)是由空肠、回肠和结肠内分泌细胞(L细胞)产生的目前已知作用最强的肠道促胰岛素分泌肽,近来发现它除刺激胰岛β细胞分泌胰岛素外,还具有促进β细胞再生、抑制食欲、调控β细胞基因特异表达等多种生物学效应。但由于其半衰期较短而限制了临床应用。类胰高糖素肽-1(GLP-1)类似物NN2211、Excendin-4克服了上述问题,延长了作用时间,为临床上治疗2型糖尿病提供了新的治疗手段。
Glucagon-like peptide-1 (GLP-1), the currently known potent secretagogue of the brain secreted by the jejunum, ileum and colon endocrine cells (L cells), has recently been found to stimulate, in addition to stimulating islet β cells Secretion of insulin, but also has to promote β-cell regeneration, suppress appetite, regulating β-cell gene-specific expression and other biological effects. However, its clinical application is limited due to its short half-life. The analogues NN2211 and Excendin-4, which are analogs of GLP-1, overcome the above problems, prolong the action time and provide a new treatment for type 2 diabetes.