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乳腺癌是女性发病率最高的恶性肿瘤~([1]),人类表皮生长因子受体2(Her-2)阳性的乳腺癌患者预后较差,使用Her-2靶向药物治疗效果较好~([2])。正确检测和评定乳腺癌的Her-2蛋白表达和基因扩增状态,对乳腺癌的临床治疗和预后判断至关重要~([3])。目前国内最常用免疫组化(IHC)和荧光原位杂交(FISH)检测Her-2状态~([4])。FISH检测成本大,不利于基层医院的普遍开展。IHC检测中常用的柠檬酸
Breast cancer is the highest incidence of malignant tumors in women ~ ([1]), the prognosis of patients with human breast epidermal growth factor receptor 2 (Her-2) -positive breast cancer is poor, Her-2 targeted drug treatment is better ~ ([2]). Correct detection and assessment of breast cancer Her-2 protein expression and gene amplification status, the clinical treatment of breast cancer and prognosis is crucial ~ ([3]). At present, the most commonly used immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) detection of Her-2 status ~ ([4]). FISH detection costs, is not conducive to the general development of primary hospital. Citric acid commonly used in IHC testing