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目的:研究大鼠小肠移植术后肠壁内在神经变化及其与小肠功能和免疫排斥间的关系。方法:SD 大鼠异位小肠移植13例,术后定期测量肠壁血管活性肠肽(VIP),P 物质(SP)神经(免疫组织化学法)以及一氧化氮(NO)神经(组织化学法)活性反应。5例正常大鼠对照研究。结果:术后早期各种神经活性下降,短期恢复,排斥期前 VIP 和 SP 活性再次明显下降,但 NO 神经反应性仍可维持。结论:小肠移植后肠壁内在神经成分和活性可保存,其变化特点可用于判断移植小肠功能和监测免疫排斥反应。
OBJECTIVE: To study the changes of intrinsic nerve in intestine after small intestinal transplantation in rats and its relationship with intestinal function and immune rejection. Methods: Thirteen cases of heterotopic small bowel transplantation in SD rats were enrolled in this study. VIP, SP substance and nitric oxide (NO) nerves (histochemical method) ) Activity. Five normal rats control study. Results: All kinds of neurological activity decreased, short-term recovery and VIP and SP activity decreased significantly after rejection, but NO neuroreactivity was still maintained. CONCLUSIONS: The intrinsic nerve composition and activity of the intestinal wall after small bowel transplantation can be preserved. The characteristics of the changes can be used to judge the function of the transplanted small intestine and to monitor the immune rejection.