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目的对７６例胃癌的２５９枚淋巴结反应性增生的组织形态进行观察，并以炎症引起的淋巴结反应性增生作对照。方法采用Ｓ－Ｐ免疫组化方法，观察淋巴结结构以及Ｔ、Ｂ淋巴细胞和巨噬细胞数量变化。结果癌引流区淋巴结：首先淋巴细胞弥漫性增生，有的可在边缘窦存在较少较小的淋巴滤泡，是以大量Ｔ细胞相对增生的早期改变；接着淋巴滤泡增生，但滤泡多较小，是以Ｂ细胞相对增生的中期改变；最后是淋巴窦扩张，大量的巨噬细胞和一些免疫母细胞增生的晚期改变。癌引流区淋巴结反应性增生在早、中、晚期不同的发展阶段中，有相应的Ｔ、Ｂ淋巴细胞和巨噬细胞变化。结论提示癌引流区淋巴结反应性增生的发生、发展，表现出机体免疫功能状态。
Objective To observe the histomorphology of reactive hyperplasia of 259 lymph nodes in 76 cases of gastric cancer, and to compare the reactive hyperplasia of lymph nodes caused by inflammation. Methods S-P immunohistochemistry was used to observe the changes of lymph node structure and T, B lymphocyte and macrophage numbers. Results Lymph nodes in cancer draining areas: diffuse lymphocyte proliferation in the first place, and some lymphoid follicles in the marginal sinuses are smaller; early changes in the relative proliferation of large numbers of T cells; lymphoid follicular hyperplasia, but more follicles The smaller is a mid-term change in the relative proliferation of B cells; the last is the expansion of lymphatic sinusoids, large numbers of macrophages, and late changes in the proliferation of some immunoblasts. The reactive hyperplasia of the lymph node in the cancer drainage area has corresponding changes in T, B lymphocytes and macrophages during different stages of development in the early, middle and late stages. Conclusions suggest that the occurrence and development of lymph node reactive hyperplasia in the draining area show the body’s immune function.