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目的观察降脂宁片治疗高脂血症的降脂疗效,为降脂宁片的临床应用和开发提供科学依据。方法选取汕尾市海丰老区人民医院2014年7月—2015年5月收治的高脂血症患者120例,随机分为两组,每组60例。治疗组给予降脂宁片,每次2片(0.52 g/片),餐后口服,2次/d;对照组给予洛伐他汀口服,每次1片(20 mg/片),每晚1次。各组均连续治疗3个月,治疗期间避免服用影响血脂代谢的其他药物。观察各组患者治疗前后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平的变化。结果治疗前两组患者血清TC、TG、LDL-C、HDL-C水平比较,差异无统计学意义(P>0.05);治疗后,治疗组患者血清TC、TG、LDL-C水平低于对照组,血清HDL-C水平高于对照组,差异有统计学意义(P<0.05)。治疗组临床控制与显效率80.00%,总有效率90.00%;对照组临床控制与显效率78.30%,总有效率90.00%。治疗组和对照组治疗后临床总有效率均为85.00%。两组疗效差异无统计学意义(P>0.05)。结论降脂宁片具有肯定的调脂作用,与洛伐他汀疗效相当,且安全性好,值得推广的应用。
Objective To observe the lipid-lowering efficacy of Jiangzhining Tablets in the treatment of hyperlipidemia and provide a scientific basis for the clinical application and development of Jiangzhining Tablets. Methods A total of 120 patients with hyperlipidemia admitted from July 2014 to May 2015 in Haifeng Old People’s Hospital of Shanwei City were randomly divided into two groups (n = 60 in each group). The treatment group were given Jiangzhining tablets, each 2 tablets (0.52 g / tablet), after oral administration, 2 times / d; the control group was given lovastatin orally, each one (20 mg / tablet) every night 1 Times. Each group were treated for 3 months continuously, avoid taking other drugs that affect blood lipid metabolism during treatment. To observe the changes of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) before and after treatment in each group. Results There was no significant difference in serum TC, TG, LDL-C and HDL-C levels between the two groups before treatment (P> 0.05). After treatment, the serum levels of TC, TG and LDL-C in the treatment group were lower than those in the control group Group, serum HDL-C levels higher than the control group, the difference was statistically significant (P <0.05). Clinical control and markedly effective rate of the treatment group was 80.00% and the total effective rate was 90.00%. The clinical control and effective rate of the control group was 78.30% with a total effective rate of 90.00%. The total effective rate of the treatment group and the control group after treatment was 85.00%. There was no significant difference between the two groups (P> 0.05). Conclusion Jiangzhining tablet has a positive lipid-lowering effect, which has the same curative effect with lovastatin and is safe and worthy of promotion.