多囊卵巢综合征是一种病因未明的异质性功能障碍性疾病,主要表现为不孕、肥胖、高血脂,胰岛素抵抗和高雄激素血症。瘦素是肥胖基因的表达产物,瘦素受体在中枢和外周组织中选择性的表达。瘦素通过瘦素受体起作用,研究发现瘦素受体与多囊卵巢综合征之间存在一定的关系,表现在瘦素受体与多囊卵巢综合征性肥胖、高脂血症、不孕、胰岛素抵抗和高瘦素血症之间的关系。 Polycystic ovary syndrome is a heterogeneous disease of unknown etiology, mainly manifested as infertility, obesity, hyperlipidemia, insulin resistance and hyperandrogenism. Leptin is an expression product of obesity genes, which are selectively expressed in the central and peripheral tissues. Leptin acts through the leptin receptor, the study found that there is a relationship between leptin receptor and polycystic ovary syndrome, manifested in leptin receptor and polycystic ovary syndrome obesity, hyperlipidemia, infertility , Insulin resistance and hyperlipidemia.