以无伤害的混合唾液浓度—紫外分光技术,通过6名志愿者研究了三种苯妥英钠制剂的人体生物利用度。这些制剂是:包以淀粉薄膜的苯妥英钠粉、普通压制片和糖衣片。此技术是早些时候由我们提出来的。在三种制剂的唾液浓度—时间曲线上以AUC比较其相对生物利用度,方差分析表明三者间无显著差异(P>0.1),结果指出三者是等效的。由於普通压制片生产上经济,故推荐此剂型。 The bioavailability of three phenytoin sodium formulations was studied by six volunteers in a non-damaging mixed saliva concentration-ultraviolet spectroscopy technique. These are: phenytoin powder coated with starch film, plain pressed tablets and sugar-coated tablets. This technique was earlier proposed by us. The relative bioavailability was compared by AUC on the saliva concentration-time curves of the three formulations, and ANOVA showed no significant difference among the three (P> 0.1), indicating that the three were equivalent. Due to the economical production of ordinary compressed tablets, it is recommended.