目的:探讨腹腔热灌注化疗对卵巢癌患者血清miR-200a的影响。方法:将82例手术治疗后的卵巢癌患者随机分为两组,观察组与对照组各41例。观察组采用全身静脉化疗联合腹腔热灌注化疗,对照组采用全身静脉化疗联合普通腹腔灌注化疗。治疗3个疗程后观察疗效,并且测定患者血清miR-200a。结果:观察组总有效率为87.8%,对照组总有效率为73.2%,两组差异有统计学意义(P<0.05)。治疗后两组患者血清miR-200a均有明显降低,观察组降低更加明显(P<0.05)。结论:腹腔热灌注化疗对卵巢癌的效果更明显,可能与减少miR-200a的表达有关系。 Objective: To investigate the effect of intraperitoneal hyperthermic chemotherapy on serum miR-200a in patients with ovarian cancer. Methods: 82 cases of ovarian cancer patients after surgery were randomly divided into two groups, the observation group and the control group of 41 cases. The observation group was treated with systemic intravenous chemotherapy combined with intraperitoneal hyperthermic perfusion chemotherapy and the control group with systemic intravenous chemotherapy combined with normal intraperitoneal perfusion chemotherapy. The curative effect was observed after 3 courses of treatment, and patient’s serum miR-200a was measured. Results: The total effective rate was 87.8% in the observation group and 73.2% in the control group, with significant difference between the two groups (P <0.05). Serum levels of miR-200a in both groups were significantly decreased after treatment, and the decrease in the observation group was more obvious (P <0.05). Conclusion: Intraperitoneal hyperthermic chemotherapy is more effective on ovarian cancer, which may be related to the decrease of miR-200a expression.