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目的研究高通量血液透析(HFD)联合血液灌流(HP)对维持性血透患者皮肤瘙痒症的影响。方法 40例血透患者随机分为对照组(HFD)和观察组(HFD+HP),在试验前及试验1、3个月后分别对两组患者瘙痒症状进行评分,同时检测透前Cr、BUN、P、Ca、iPTH、ALB、CRP等指标并进行比较。结果观察组较对照组瘙痒症状在1个月、3个月时均明显改善[(5±1)分vs.(6±1)分;(3±1)分vs.(5±1)分],差异有统计学意义(P<0.05);血清BUN、Cr、Ca差异无统计学意义(P>0.05);但CRP、ALB、iPTH、P在2种血液净化模式下有明显不同,差异有统计学意义(P<0.05)。结论 HFD+HP能减轻患者的皮肤瘙痒,降低炎症指标,改善营养不良,进而可能会提高血液透析者的生存质量。
Objective To investigate the effects of high-flux hemodialysis (HFD) combined with hemoperfusion (HP) on pruritus in maintenance hemodialysis patients. Methods Forty patients with hemodialysis were randomly divided into control group (HFD) and observation group (HFD + HP). Pruritus symptoms were evaluated before and after 1, 3 months. The levels of Cr, BUN, P, Ca, iPTH, ALB, CRP and other indicators and compared. Results The pruritus symptoms in the observation group were significantly improved at 1 month and 3 months compared with the control group [(5 ± 1) vs. 6 ± 1; (3 ± 1) vs. 5 ± 1 ], The difference was statistically significant (P <0.05). The serum levels of BUN, Cr and Ca had no significant difference (P> 0.05). However, CRP, ALB, iPTH and P were significantly different in the two blood purification modes, There was statistical significance (P <0.05). Conclusions HFD + HP can reduce skin pruritus, reduce inflammation and improve malnutrition, which may improve the quality of life of hemodialysis patients.