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目的:探讨子宫恶性肿瘤腹腔镜根治术与常规开腹根治术的疗效对比评价及RT-PCR技术跟踪检测微小残留病变的临床应用效果。方法:统计符合实验标准的子宫恶性肿瘤患者104例随机分为两组,对照组52例应用常规开腹根治术术式,观察组52例应用腹腔镜根治术术式,统计术后复发转移情况两组进行比较。结果:两组患者手术时间、术中失血量、切除淋巴结数目、术后发热时间等比较差异有统计学意义(P<0.01),术后并发症差异有统计学意义(P<0.05),子宫功能恢复时间差异无统计学意义(P>0.05)。2年内转移复发率观察组为5.8%,对照组为13.5%,观察组患者的微小残留病变MRD与对照组差异有统计学意义(P<0.05)。结论:子宫恶性肿瘤根治术采用腹腔镜技术安全可靠,可以明显降低术后复发转移率;采用RT-PCR技术跟踪检测微小残留病变可提高患者术后的生存期及生存质量。
OBJECTIVE: To compare the efficacy of laparoscopic radical mastectomy with conventional open radical mastectomy for malignant tumors of the uterus, and to evaluate the clinical effects of RT-PCR in the detection of minimal residual lesions. Methods: A total of 104 patients with malignant uterine tumors who meet the experimental criteria were randomly divided into two groups. The control group received routine laparoscopic radical mastectomy. In the observation group, 52 cases were treated with laparoscopic radical mastectomy. The recurrence and metastasis The two groups are compared. Results: The operation time, intraoperative blood loss, the number of resected lymph nodes and the postoperative fever time were significantly different between the two groups (P <0.01). The postoperative complications were statistically significant (P <0.05) Functional recovery time difference was not statistically significant (P> 0.05). The recurrence rate of metastasis within 2 years was 5.8% in the observation group and 13.5% in the control group. There was significant difference between the MRD of the minimal residual disease and the control group in the observation group (P <0.05). Conclusions: Laparoscopic surgery is safe and reliable in the radical mastectomy of malignant uterine tumor, which can significantly reduce the recurrence and metastasis rate. Follow-up detection of minimal residual disease by RT-PCR can improve the postoperative survival and quality of life of patients.