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血红蛋白(以下简称 Hb)E 是一种慢泳异常 Hb,其结构分析首先由 Hunt 等于1964年完成,证实是 Hb 的β—珠蛋白肽链N 端第26位谷氨酸残基被赖氨酸所取代。近年来国内外均发现有多种 HbE 的类型,据文献报道东南亚地区发生率最高,在我国广西、广东、四川、湖南、湖北等地都陆续有报告,本文报道了在海口市区血红蛋白分子病普查中发现的 HbE 特征及其一个家系的一级结构分析结果,并对 HbE 的生化遗传
Hemoglobin (hereinafter referred to as Hb) E is a slow swimming abnormal Hb, its structural analysis was first completed by Hunt in 1964, confirmed that Hb β-globin peptide N-terminal 26 glutamic acid residue lysine Replaced. In recent years, there are many types of HbE both in China and abroad. According to the literature, the highest incidence is found in Southeast Asia, and reported successively in Guangxi, Guangdong, Sichuan, Hunan, Hubei and other places in China. This paper reports the hemoglobin molecular disease HbE characteristics found in the census and primary family structure analysis results of a pedigree, and HbE biochemical genetic