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采用血清药理学方法,探讨真武汤对人胎肾小球系膜细胞外基质(ECM)不同成分的作用,为真武汤防治肾小球硬化的临床应用提供实验依据。结果真武汤能够明显降低ECM成分中层粘连蛋白(LN)和Ⅳ型胶原(Col Ⅳ)的含量。表明真武汤对ECM的增殖具有明显的抑制作用。
Serum pharmacological methods were used to investigate the effects of Zhenwu Decoction on different components of human fetal mesangial extracellular matrix (ECM), which provided an experimental basis for the clinical application of Zhenwu Decoction in preventing and treating glomerulosclerosis. Results Zhenwu Decoction can significantly reduce the content of laminin (LN) and type IV collagen (Col IV) in ECM components. It shows that Zhenwu Decoction has obvious inhibitory effect on the proliferation of ECM.