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目的 了解呼吸道合胞病毒 (RSV)的亚型感染情况及其所致毛细支气管炎的临床特点。方法 对12 1例临床诊断为毛细支气管炎患儿的鼻咽分泌物采用巢氏PCR方法进行RSV及亚型检测 ,并分析亚型感染患儿的临床资料。结果 ①RSV阳性 87例 (71.9% ) ,其中A亚型 6 0例 ,B亚型 2 7例 ;②Bierman’s病情评分显示B亚型毛细支气管炎的临床症状较A亚型轻 ,恢复快 ;③A、B亚型RSV感染毛细支气管炎患儿在发病年龄、发热、血气、胸片上无显著性差异 ;④与间接免疫荧光等方法相比较 ,巢氏PCR是检测RSV灵敏度较高的方法。结论 B亚型RSV毛细支气管炎的临床症状较A亚型为轻
Objective To understand the subtype infection of respiratory syncytial virus (RSV) and its clinical characteristics of bronchiolitis. Methods The nasopharyngeal secretions of 12 children with bronchiolitis were detected by RSV and subtype detection by nested PCR. The clinical data of children with subtype infection were analyzed. Results ① The positive rate of RSV was 87 cases (71.9%), of which 60 cases were A subtype and 27 cases subtype B; ② The Bierman’s disease score showed that the clinical symptoms of subtype B bronchitis were lighter and recovered faster than A subtype; ③A, B Subtype RSV infection in children with bronchiolitis in age of onset, fever, blood gas, chest radiograph no significant difference; ④ indirect immunofluorescence and other methods compared to Nestle PCR is to detect RSV high sensitivity method. Conclusion The clinical symptoms of subtype B RSV bronchiolitis are lighter than those of subtype A