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目的观察已烯雌酚加米索前列醇与单纯米索前列醇用于绝经后妇女取出宫内节育器(intrauterine contraceptive device,IUD)术前用药的临床效果。方法将绝经半年以上要求取出IUD的妇女120例分成两组,用已烯雌酚加米索前列醇60例为观察组,单用米索前列醇60例为对照组,比较两组术中宫颈软化程度、出血量、疼痛情况、取器时间及其成功率。结果观察组术中宫颈软化好、疼痛轻、出血量少、取器时间短、成功率高,与对照组比较,差异有统计学意义(P<0.05)。结论已烯雌酚加米索前列醇用于绝经后妇女取器术前用药的临床效果优于单纯使用米索前列醇。
Objective To observe the clinical effect of diethylstilbestrol plus misoprostol and simple misoprostol for the preoperative administration of intrauterine contraceptive device (IUD) in postmenopausal women. Methods A total of 120 women with IUD after menopause for more than half a year were divided into two groups. 60 patients were treated with diethylstilbestrol plus misoprostol, and 60 patients with misoprostol alone were used as control group. Degree of softening, amount of bleeding, pain, taking time and success rate. Results The patients in the observation group had good cervix softening, less pain, less bleeding, shorter time of taking up the device, and higher success rate. The difference was statistically significant (P <0.05). Conclusion The use of diethylstilbestrol and misoprostol in premenopausal women is superior to the simple use of misoprostol in premenopausal women.