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作者对肺炎患儿(44例)和肺炎合并心衰患儿(13例)作了血浆心钠素(ANP)动态观察。ANP测定结果:肺炎急性期为98.94±66.41pg/ml.恢复期为58.00±18.04pg/ml;肺炎心衰急性期为408.72±359.83pg/ml,恢复期为122.52±117.26pg/ml。两组的恢复期与急性期比较,ANP均显著降低(P分别<0.01和0.05),提示血浆ANP水平的变化可作为疗效观察的一个指标。作者还提出,严重心衰患者血浆ANP含量近于或低于正常可能是预后不良的预兆。
The authors made a dynamic observation of plasma atrial natriuretic peptide (ANP) in children with pneumonia (44 cases) and children with pneumonia complicated with heart failure (13 cases). The results of ANP showed that the acute phase of pneumonia was 98.94 ± 66.41pg / ml, the recovery was 58.00 ± 18.04pg / ml, the acute phase of pneumonia was 408.72 ± 359.83pg / ml and the recovery was 122.52 ± 117.26pg / ml. ANP was significantly lower in both recovery and acute phases (P <0.01 and P <0.05, respectively), suggesting that changes in plasma ANP may be an indicator of efficacy. The authors also suggest that plasma ANP levels in patients with severe heart failure may be a prognostic indicator of poor prognosis with near or under-normal plasma levels of ANP.