肝肾综合征(Hepatorenal syndrome,HRS)的定义:肝病患者发生的不能完全解释的肾功能不全,同时缺乏能导致肾衰的临床、实验室或解剖学等证据。HRS 大多数发生在肝硬化患者,尤其有大量腹水时。多数有一定诱因,如强烈利尿、大量放腹水、消化道出血、严重黄疸及服用某些影响肾脏前列腺素合成的药物(如非甾类抗炎剂醋柳酸、消炎痛、保太松、布洛芬、氨基比林等)。HRS 的发生与下列因素有关:1.有效循环血容量降低致肾血浆流量及肾小球滤过率降低,引起少尿,故各种减少血容量的因素如进食少、呕吐、腹泻、强烈利尿等都可诱发或 Definition of Hepatorenal Syndrome (HRS): Incomplete renal insufficiency that occurs in patients with liver disease, with a lack of evidence of clinical, laboratory or anatomic consequences of renal failure. Most HRS occurs in patients with cirrhosis, especially when there is a large amount of ascites. Most have some incentives, such as strong diuretic, a large amount of ascites, gastrointestinal bleeding, severe jaundice and taking certain drugs that affect renal prostaglandin synthesis (such as non-steroidal anti-inflammatory drugs salicylic acid, indomethacin, Paul pine, cloth Ibuprofen, aminopyrine, etc.). The occurrence of HRS and the following factors: 1. Effective reduction of circulating blood volume induced renal plasma flow and glomerular filtration rate decreased, causing oliguria, so a variety of reduced blood volume factors such as eating less, vomiting, diarrhea, strong diuresis And so can be induced or