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头孢三嗪噻肟具有较长的血清半衰期,体外能杀灭儿科常见细菌。本文采用每日1次大剂量治疗细菌性脑膜炎和其他严重儿科感染,以评价其安全性和有效性。共观察71例病人。57例细菌培养阳性,其中包括:脑膜炎26例,心内膜炎3例,肾盂肾炎7例,骨髓炎6例,脓肿4例,脓毒性关节炎3例,败血症2例和混合感染6例。主要分离到的细菌是流感嗜血杆菌(23例)、大肠杆菌(9例)和金黄色葡萄
Cefotaxime has long serum half-life, in vitro to kill common pediatric bacteria. In this paper, a large daily dose of bacterial meningitis and other serious infections in children to evaluate its safety and effectiveness. A total of 71 patients were observed. 57 cases of bacterial culture positive, including: 26 cases of meningitis, endocarditis in 3 cases, 7 cases of pyelonephritis, osteomyelitis in 6 cases, 4 cases of abscess, 3 cases of septic arthritis, sepsis in 2 cases and 6 cases of mixed infection . The main bacteria isolated were Haemophilus influenzae (23 cases), Escherichia coli (9 cases) and golden yellow grape