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目的 探讨基质金属蛋白酶-9(metalloproteinase-9,MMP-9)和血管内皮细胞生长因子(Vascular Endothelial Growth Factor,VEGF)在胆囊腺癌的表达及临床意义。方法 应用免疫组化SP法检测57例胆囊腺癌组织MMP-9与VEGF的表达,并与患者临床病理指标进行分析。结果 胆囊腺癌组织加MMP-9与VEGF阳性率分别为56.1％、52.6％。MMP-9的表达与胆囊腺癌的病理分级、临床分期密切相关(P<0.05)。MMP-9与VEGF在胆囊腺癌的表达呈正相关。结论MMP-9与VEGF参与胆囊腺癌的发生发展过程,可作为评估胆囊腺癌生物学行为的一项指标。
Objective To investigate the expression and clinical significance of metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) in gallbladder adenocarcinoma. Methods The expression of MMP-9 and VEGF in 57 cases of gallbladder adenocarcinoma was detected by immunohistochemical SP method, and the clinical and pathological parameters were analyzed. Results The positive rates of MMP-9 and VEGF in gallbladder adenocarcinoma were 56.1% and 52.6% respectively. The expression of MMP-9 was closely related to the pathological grade and clinical stage of gallbladder adenocarcinoma (P <0.05). MMP-9 and VEGF expression in gallbladder adenocarcinoma was positively correlated. Conclusions MMP-9 and VEGF are involved in the development of gallbladder adenocarcinoma and may be used as an index to evaluate the biological behavior of gallbladder adenocarcinoma.