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探讨哮喘患儿急性发作期，缓解期外周血ET、TNF－a水平变化，并分析其相关性。本实验选择47例哮喘患儿，32名正常儿童作为对照组，分别在哮喘急性发作期和缓解期采静脉血，用放射免疫法检测ET、TNF-a水平。结果发现发作期哮喘息儿血浆ET明显高于正常儿童（分别为91．26±21．606，54．42±18．602ng／L，P＜0．0005），缓解期降至正常水平（64．50±20．159ng／L，P＞0．05）重症组高于轻中症组建（分别为108．27±19.50879．32±20．61ng／L，P＜0．005），发作期哮喘息儿血清TNF-a水平亦明显高于正常儿童（分别为1．877±0．39，1．176±0．39ng／L，P＜0．005）缓解期降至正常水平（1．183±0335ng／L，P＞0．05）重症组高于轻中症组（分别为2.18±0．441．65±035ng／L，P＜0．0005）ET和TNF-a水平呈显著正相关。提示ET和TNF-a在哮喘发病机制中有其重要作用．对哮喘的病情判断及预后有一定指导意义。
To investigate the changes of ET and TNF-a levels in peripheral blood of children with acute asthma and remission, and to analyze their correlation. In this experiment, 47 asthmatic children and 32 normal children were selected as the control group. Venous blood was collected during acute exacerbation and remission of asthma. The levels of ET and TNF-a were detected by radioimmunoassay. The results showed that the incidence of asthma infantile infantile plasma ET was significantly higher than normal children (91.26 ± 21.606,54.42 ± 18.602ng / L, P <0.0005), remission to normal levels (64 .50 ± 20.159ng / L, P> 0.05) in severe group was higher than that in mild disorder (108.27 ± 19.50879.32 ± 20.61ng / L, P <0.005, respectively) Serum levels of TNF-α were also significantly higher than those of normal children (1.877 ± 0.39, 1.176 ± 0.39 ng / L, P <0.005, respectively) ± 0335ng / L, P> 0.05). The levels of ET and TNF-a in severe group were significantly higher than those in mild disorder group (2.18 ± 0.441.65 ± 035ng / L, P <0.0005) . Tip ET and TNF-a in the pathogenesis of asthma has an important role. Judgment and prognosis of asthma have some guiding significance.