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目的观察防哮汤对哮喘稳定期患儿临床症状、血清IL-4、IFN-γ水平的影响,验证防哮汤在纠正Th1/Th2平衡失调上的效果。方法采用随机、平行对照的方法,对80例哮喘稳定期患儿进行临床研究。治疗组给予防哮汤口服,对照组给予童康片口服,服药1个月后随访6个月,对两组患儿进行疗效评价,并对两组治疗前后血清IL-4、IFN-γ及IL-4/IFN-γ进行数据分析。结果治疗组哮喘发作次数显著低于对照组,差异有统计学意义(P<0.05)。血清IL-4、IFN-γ的数据分析表明,治疗组血清IL-4明显降低、IFN-γ升高,IL-4/IFN-γ较用药前下降。结论防哮汤具有平衡Th1/Th2的作用,进而降低哮喘的反复发作。
Objective To observe the effect of Anti-Asthmatic Decoction on clinical symptoms, serum IL-4 and IFN-γ in asthmatic children with stable asthma, and to verify the effect of anti-asthmatic decoction on correcting the imbalance of Th1 / Th2. Methods A randomized, parallel-controlled trial of 80 asthmatic children with stable clinical studies. The treatment group was given oral anti-asthmatic soup, the control group was given Tongkang tablets orally, after 1 month of medication was followed up for 6 months, the efficacy of the two groups were evaluated, and the two groups before and after treatment serum IL-4, IFN- and IL-4 / IFN-γ for data analysis. Results The number of asthma attacks in the treatment group was significantly lower than that in the control group (P <0.05). Data analysis of serum IL-4 and IFN-γ showed that serum IL-4, IFN-γ and IL-4 / IFN-γ in treatment group were significantly lower than those before treatment. Conclusion Anti-Asthma Decoction has the function of balancing Th1 / Th2, thereby reducing the recurrence of asthma.