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目的观察每晚顿服苯巴比妥全日量对癫疒间患者的疗效、不良反应及生活质量的影响。方法将60例癫疒间患者随机分为顿服组和对照组,每组30例。顿服组苯巴比妥全日量每晚顿服;对照组苯巴比妥全日量分3次服用。1年后进行疗效、生活质量及不良反应评价。结果顿服组与对照组总有效率分别为83.3%和80%,差异无显著性(P>0.05);顿服组患者困倦、抑郁、焦虑等不良反应及漏服药次数显著少于对照组,生活质量优于对照组(P<0.05～0.01);两组均未见特殊毒性反应。结论苯巴比妥每晚顿服全日量治疗癫疒间与全日量分3次服用疗效基本一致,顿服组患者的生活质量明显优于对照组,不良反应少于对照组,安全可行。
Objective To observe the efficacy, side effects and quality of life of phenobarbital full-daily dose in patients with epilepsy. Methods 60 cases of epilepsy patients were randomly divided into Dayton group and control group, 30 cases in each group. Dayton group phenobarbital full Day dose Dayton clothing; control group phenobarbital full day dose 3 times. After 1 year efficacy, quality of life and adverse reactions evaluation. Results The total effective rate of Dayu service group and control group were 83.3% and 80%, respectively, with no significant difference (P> 0.05). The adverse reactions such as drowsiness, depression, anxiety and the number of missed medication in Dayun service group were significantly less than those in control group The quality of life was better than that of the control group (P <0.05 ~ 0.01). No specific toxicity was observed in both groups. Conclusion Phenobarbital daily dose of Dayton dose of epilepsy and full-dose three times the same efficacy, Dayton service group was significantly better than the control group quality of life, adverse reactions less than the control group, safe and feasible.