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肝刺激物(hepatic stimulator substance,HSS)是从初断乳大鼠肝和部分肝切除后的再生肝中发现的一种肝脏刺激因子,它存在于新生肝和再生肝的肝细胞胞液中,能刺激肝细胞有丝分裂,促进肝细胞再生和肝细胞DNA的合成。与其他肝细胞因子不同,HSS的作用只有组织特异性,而没有种属特异性,目前已从猪、狗、兔等多种动物的乳肝组织及人胎肝组织提取出HSS。大量研究证明,从哺乳动物提取的HSS对CCl4、D-(+)-氨基半乳糖、硫代乙酰胺(TAA)、乙醇造成的大鼠急性肝损伤有明显的保护作用[1,2]。研究表明鲨鱼组织提取物有可能用于提高和改善人类机体免疫状况[3]。本文探讨了其对小鼠急性肝损伤的影响。
Hepatic stimulator substance (HSS) is a type of hepatic stimulating factor found in the regenerated liver after partial hepatectomy and in primary weanling rats. It exists in the cytosol of hepatocytes of neonatal and regenerative liver, Can stimulate the mitosis of liver cells, promote liver cell regeneration and liver cell DNA synthesis. Unlike other liver cytokines, HSS is tissue-specific and has no species-specific effects. HSS has been extracted from the liver tissues of various animals such as pigs, dogs and rabbits and human fetal liver tissues. Numerous studies have shown that HSS extracted from mammals has a significant protective effect on acute liver injury induced by CCl4, D - (+) - galactose, thioacetamide (TAA) and ethanol in rats [1,2]. Research shows that shark tissue extracts may be used to improve and improve the immune status of human body [3]. This article explores its impact on acute liver injury in mice.