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目的 :查明新兵中以血清单项ALT升高为主要特征的肝损害患者的病因、传播途径和临床特点。方法 :对 2 0 7名 2 0 0 1年入伍新兵进行流行病学调查 ,对血清和部分粪便标本进行肝功能和各种肝炎病毒标志物检测 ,对ALT升高者进行临床特点分析 ,对部分ALT升高者进行肝穿活检。结果 :血清TTVDNA阳性 10 8例 ,占 5 2 .13% ,5人粪便中检出TTVDNA ;ALT升高 79例 ,占 38.16 % ;ALT升高可排除各种中毒因素 ,血清甲、乙、丙、丁、戊、庚型肝炎病毒标志物均阴性 ;ALT升高者均无明显症状和体征 ,肝组织活检均有肝细胞肿胀变性、点状坏死等病理改变。结论 :本次ALT升高可能是由TTV引发的非甲～庚型病毒性肝炎 ;传播途径是消化道
OBJECTIVE: To identify the etiology, route of transmission and clinical features of recurrent liver damage in recruits with the main feature of elevated serum ALT. Methods: Two hundred and seventy recruits from 2001 to 2001 were enrolled into the epidemiological survey, the serum and some stool specimens were tested for liver function and various hepatitis virus markers. The clinical features of those with elevated ALT were analyzed. ALT elevated liver biopsy. Results: The positive rate of TTVDNA in serum was 108, accounting for 52.13%. The TTV DNA was detected in 5 human faeces. The ALT was elevated in 79 cases (38.16%). ALT elevation could eliminate various poisoning factors. Serum A, B and C , D, E and G were all negative. No significant symptoms and signs were found in those with elevated ALT. Liver biopsy showed pathological changes of hepatocyte swelling and degeneration. Conclusion: This increase in ALT may be caused by TTV non-A ~ G hepatitis; transmission is the digestive tract